Novel Mechanisms of Sympathetic Regulation in Chronic Heart Failure
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چکیده
منابع مشابه
Novel mechanisms of sympathetic regulation in chronic heart failure.
The idea that activation of the sympathetic nervous system is part and parcel of the apparent positive feedback cycle of cardiac deterioration in the setting of chronic heart failure (CHF) is not a new one. Several reviews have clearly summarized the evidence for this concept using both clinical data and information from experimental models.1–4 Evidence from both neural recordings and measureme...
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Heart failure (HF) is a serious debilitating condition with poor survival rates and an increasing level of prevalence. HF is associated with an increase in renal norepinephrine (NE) spillover, which is an independent predictor of mortality in HF patients. The excessive sympatho-excitation that is a hallmark of HF has long-term effects that contribute to disease progression. An increase in direc...
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It is well recognized that the initial myocardial injury and associated decrease in left ventricular (LV) function activate progressively a variety of systems, which in the longterm contribute to progressive cardiac dysfunction and clinical heart failure. Studies on the pathophysiology of the CHF syndrome have extensively focused on the activity of systems such as the sympathetic nervous system...
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Stewart JM. Mechanisms of sympathetic regulation in orthostatic intolerance. J Appl Physiol 113: 1659 –1668, 2012. First published June 7, 2012; doi:10.1152/japplphysiol.00266.2012.—Sympathetic circulatory control is key to the rapid cardiovascular adjustments that occur within seconds of standing upright (orthostasis) and which are required for bipedal stance. Indeed, patients with ineffective...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2006
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000246614.47231.25